PHARMACEUTICAL CALCULATIONS | PAST PAPERS | PHARMACY PST LEVEL 4

PHARMACEUTICAL CALCULATIONS | PAST PAPERS | PHARMACY PST LEVEL 4

1.      How much Lidocaine is required to prepare 1: 1000, 30ml solution of Lidocaine?
A. 10 mg
B. 0.03 mg
C. 30 mg                                               
D. 300 mg

E.0.003mg

 

2.      If 60 gm of 1% hydrocortisone is mixed with 80 gm of 2.5% of hydrocortisone, what is the % of hydrocortisone in final mixture?
A. 2.2 % w/w
B. 1.85 % w/w                                   
C. 0.25 % w/w
D. 1.75 % w/w

E.0.8%

 

3.      If the dose of the drug is 200mg,how many doses are contained in 10g

A.    100doses

B.     20doses

C.     50doses                                   

D.    200doses

E.     5doses

 

4.          How many tea spoonful will be prescribed in each dose of an elixir if 180ml contained 18doses?

A.    1teaspoonful

B.     5teaspoonful

C.     18teaspoonful                                  

D.    3teaspoonful

E.     2teaspoonful

 

 

5. How many millilitre of a liquid medicine would provide a patient with 2 tablespoonful dose to be taken three times a day for 16 days?

A.    240ml

B.     480ml

C.     1440ml                                

D.    500ml

E.     380ml

6. Given a 20%w/v solution of chlorhexidine gluconate, what volume is required to make 400ml of a 2%w/v solution

A.    40ml

B.     20ml                                     

C.     80ml

D.    2ml

E.     4ml

7. Which of the following shows the correct amounts of sodium chloride and anhydrous glucose present in 500ml of intravenous infusion containing sodium chloride 0.18%w/v and anhydrous glucose 4%w/v

A.    Sodium chloride 0.18g and anhydrous glucose 20.0g                           

B.     Sodium chloride 0.90g and anhydrous glucose 20.0g

C.     Sodium chloride 0.90g and anhydrous glucose 40.0g

D.    Sodium chloride 1.80g and anhydrous glucose 20.0g

E.     Sodium chloride 1.80g and anhydrous glucose 40.0g

8. If 5g of boric acid is added to 100ml .What is the percentage strength (w/w) of the solution

A.    3.6%

B.     4.76%

C.     2.3%                                

D.    5%

E.     4.65

9. How many grams of phenol should be used to prepare 240g 0f a 5 %( w/w) solution in water

A.    6g

B.     14g

C.     24g                                     

D.    12g

E.     36g

 

10. What is the % of acetic acid in 1:20?

A.    2%

B.     0.5%

C.     1%                                        

D.    5%

E.     1.5%

SECTION B: MULTIPLE TRUE AND FALSE QUESTIONS         20

This section consist of 8 questions with five options each .Write the word “TRUE” and not letter “T” for a correct statement and the word “FALSE” not letter “F” for the incorrect statement. Each correct response carries equal  of 0.5

1.      Percentage weight-in-volume indicates;

A.    ................ The number of parts by weight (gm) of active ingredient contained in the total volume of the solution or mixture considered as 100 parts by volume

B.     ................The number of parts by weight (kgm) of active ingredient contained in the total volume of the solution or mixture considered as 100 parts by volume

C.     .............The number of parts by weight (gm) of active ingredient contained in the total volume of the solution or mixture considered as 1000 parts by volume

D.    ................The number of parts by weight (mg) of active ingredient contained in the total volume of the solution or mixture considered as 100 parts by volume

E.     ...............The number of parts by weight (gm) of active ingredient present in  the total volume of the solution or mixture considered as 10 parts by volume

2.      When a ratio strength for example 1:1000, is used to designate a concentration, it is to be interpreted as follows:

A.    ..................For solids in liquids = 1 gm of solute or constituents in 1000 mL of solution or liquid preparation

B.     ................For liquids in liquids = 1 mL of constituents in 1000 mL of solution or liquid preparation

C.     ..................For liquids in liquids = 1mL of constituents in 1000L of solution or liquid preparation

D.    ................For liquids in liquids = 1 gm of constituents in 1000g of solution or liquid preparation

E.     .................For liquids in liquids = 1 mL of constituents in 100mL of solution or liquid preparation

 

 

 

3. Regarding common strength of pharmaceutical preparations

A.    .............  In case of solid ingredients in liquid vehicle ,the ratio is w/v

B.     ............  In case of a liquid ingredient in a solid vehicle ,the ratio is w/w

C.     ............  In case of both ingredients are liquid, the ratio is v/v

D.    ............  In case of both ingredients are solids ,the ratio is w/v

E.     ...........  Can be expressed in ratio strength

4. Dilution of a substance

A.    ..............Addition of a concentration of a substance

B.     ...............Addition of the vehicle to lower strength of solution

C.     ..................Addition of the vehicle will increase the concentration of the drug

D.    ...............Decreasing the number of particles in a substance will lower the concentration

E.     .................Diluent includes phenol, water and DW5%

5. Pharmaceutical drugs in children may differ from adults for several reasons such as

A.    ....................Age,body compostion,sex

B.     ..................Sex,gender,function of the liver and  kidney

C.     ..................Age, maturation of enzymatic throughout the life span from neonates to adult

D.    .................Gender, age

E.     ..............Functional of the liver and kidney

6. Concerning heparin

A.    ..............A drug that has coagulant effect

B.     ..............Increasing clotting time and used as anticoagulant

C.     ..............Include high molecular weight heparin

D.    ...............Heparin salts are administered as salts by intravenous infusion

E.     ............Fractioned heparin is the most used

7. Parts per million (ppm)

A.    .............The strength of very dilute solution is commonly expressed in terms of parts per million

B.     ................The number of parts of the agent per one million parts of the whole

C.     .................Examples are fluorinated drinking water

D.    ..................Ppm concentration may be expressed in quantitatively equivalent values of the percentage strength or ratio strength

E.     ................Used in calculating the ratio strength of a substance in the whole product

 

 

 

8. Following are the different measures of weight

A.     ……………………1 kilogram (kg)=1000000 milligram

B.      …………………...1 hectogram (hg)=100 gram

C.      …………………...1 dekagram (dag)=10 gram

D.     ……………………1 gram (g)=1gram

E.      ………………….1 decigram (dg) =0.1 gram

 

SECTION C: MATCHING ITEMS QUESTIONS                                       10

In each question, match the items from the column B with those of column A by writing the correct CAPITAL LETTER on the response column, each response carry 1, one option in column B should be used only.

PART A: About the households units, match options in column A with the corresponding options in column B

SNO.

GROUP A

ANSWERS

GROUP BS

1

1gallon

 

A:454liters

2

1pint

 

B:454mls

3

1pound

 

C:568mls

4

1grain

 

D:0.454kg

5

1/2Table spoonful

 

E:0.545kg

 

 

 

F:0.454mgs

 

 

 

G:65mg

 

 

 

H:7.5mls

 

PARTB: Concerning the metric units of length, match options in column A with the corresponding options in column B

SNO.

GROUPA

ANSWERS

A:

 

1

1dm

 

B:0.01km

 

2

1dam

 

C:100dm

 

3

1mm

 

D:1000mm

 

4

1Km

 

E:0.000001M

 

5

1Micro meter

 

F:100mm

 

 

 

 

G:0.001m

 

 

 

 

 

 

 

SECTION D: SHORT ANSWER QUESTIONS                                                  40

There are eight (8) questions in this section, write your answer in space provided wherever provided under the question. Each question carries 05 only.

 

 

 

 

1 a. Calculate the dose of a child weighs 17.5kg when the adult dose is 0.5kg (2.5)

          b.If the adult dose of a drug is 75mg, what will be the dose for a child weighing 40          lb? (2.5)

……………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………..

2: i) what is the density of a solution weigh 250g and 248mL? (2.5)

   ii) What is the specific gravity of 365mL of glycerol weigh 460g? (2.5)

………………………………………………………………………………

3. What is the percentage strength (v/v) of alcohol in a mixture of 3000 mL of 40% (v/v) alcohol, 1000 mL of 60% (v/v) alcohol, and 1000 mL of 70% (v/v) alcohol? Assume no contraction of alcohol after mixing (05)

………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………

 

    4a) Calculate the volume of alcohol 90% v/v needed to prepare 400 mL of alcohol 70% v/v (2.5)

b) How many mL of formalin 2% v/v will be prepared from 350 mL of formalin 36% v/v (2.5)?

………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………

5: If 50 glycerine suppositories are made from the following formula, how many millilitres of glycerine having a specific gravity of 1.25, would be used in the preparation of   96 suppositories (05)

Glycerine ...........................91g

Sodium stearate...................9g

Purified water.....................5g

………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………..

 

 

 

 

 

 

 

     6: How many millilitres of liquefied phenol should be used in compounding the following prescription? (05)

Rx Liquefied phenol……………………2.5%

     Calamine lotion………….…ad 240.0 mL

     Sig. For external use

………………………………………………………………………………………………………………………………………………………………………………

……………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………….            

7: In preparing 250ml of a certain solution a pharmacist used 4ml of a liquefied phenol. What was the percentage v/v of a liquefied phenol in the lotion? (05)

………………………………………………………………………………                  

                                                                                     

8. The concentration of the drug additive in an animal feed is 12.5 ppm. How many mgs of drugs should be used in preparing 5.2 kg of feed? (05)

                               

……………………………………………………………………………………………………………………………………………………………………………………………………………….

 

SECTION E: LONG ANSWER QUESTIONS                                                                 20

This section carries two questions, each question carries 10, start a new page for a new question

1. An intravenous infusion contained 20,000 units of heparin sodium in 1000 mL of D5W. The rate of infusion was set at 1600 units per hour for a 160-lb. patient (10)

Calculate:

 (a) The concentration of heparin sodium in the infusion, in units/mL (02)

(b) The length of time the infusion would run, in hours (03) 

(c) The dose of heparin sodium administered to the patient, on a unit/kg/minute basis (05)

 2a) the label instructions for an ampicillin product call for addition of 78 mL of water to make 100 mL of constituted suspension such that each 5mL contains 125 mg of Ampicillin.  What is the volume occupied by dry powder and the total drug present? (05)

 

2b) the label instructions for an ampicillin product call for addition of 78 mL of water to make 100 mL of constituted suspension such that each 5mL contains 125 mg of Ampicillin.  If the physician desires an ampicillin concentration of 100 mg/5 mL (rather than 125 mg/5 mL), how many millilitre of water should be added to the dry powder? (05)

 

                                     

 

 

                                            

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